Neuroscience
See neural tissues clearly
The high heterogeneity and autofluorescence of brain and neural tissue present technical challenges when using conventional imaging techniques to decipher different cell types and intricate spatial relationships in the study of neurodegenerative disease or neuro-oncology.
Imaging Mass Cytometry™ (IMC™) produces clear, easy-to-interpret signals from neural tissue, eliminating autofluorescence interference with metal-labeled antibodies.
Download neuroscience lookbook
Mapping the neuro-oncological cellular landscape
Spatial phenotyping with IMC technology enables high-quality neurological and immunological readouts of over 40 proteins simultaneously in various neoplasms in human and mouse neurological tissues. Choose from a suite of ready-made panels to quickly create high-plex panels that provide comprehensive coverage of immuno-oncological processes in precious samples.
Human
Neuro-Oncology
Target neuronal-specific markers in human gliomas with the Glioblastoma IMC Panel, 5 Antibodies. Reveal spatial complexity in heterogeneous brain tissue without tissue degradation and autofluorescence artifacts usually observed in brain tissue.
Human
Neuro-Oncology
Target neuronal-specific markers in human gliomas with the Glioblastoma IMC Panel, 5 Antibodies. Reveal spatial complexity in heterogeneous brain tissue without tissue degradation and autofluorescence artifacts usually observed in brain tissue.
Mouse
Neuro-Oncology
Study 35 markers of the mouse neurological tumor microenvironment with the Maxpar OnDemand Mouse Neuro-Oncology IMC Bundle.
Mouse
Neuro-Oncology
Study 35 markers of the mouse neurological tumor microenvironment with the Maxpar OnDemand Mouse Neuro-Oncology IMC Bundle.
Products
Visualize structure and cellular composition within the brain tumor microenvironment.
Glioblastoma IMC™ Panel, 5 Antibodies
The Glioblastoma IMC™ Panel, 5 Antibodies provides essential markers for the identification and characterization of glioblastoma cells. This panel includes 4 Maxpar OnDemand Antibodies targeting epidermal growth factor receptor (EGFR), nestin, SOX2, matrix metalloproteinase-9 (MMP9), and 1 Maxpar antibody targeting vimentin. This panel is optimized for use in human FFPE tissue sections, with reported reactivity in mouse.
Human Neuro Expansion IMC™ Panel, 3 Antibodies
The Human Neuro Expansion IMC™ Panel, 3 Antibodies is designed to complement the Maxpar Neuro Phenotyping IMC Panel Kit (201337) by providing additional markers for microglia, synapses, and neuronal phenotyping. This panel includes 3 Maxpar OnDemand Antibodies targeting transmembrane protein 119 (TMEM119), synaptophysin (SYP), and β III tubulin (TUBB3). This panel is optimized for use in human FFPE tissue sections.
Maxpar Neuro Phenotyping IMC Panel Kit
The Maxpar Neuro Phenotyping IMC™ Panel Kit is a seven-marker kit that includes validated human and mouse reactive antibodies against Iba1, GFAP, NeuN, S100β, MAP2, CD34 and Olig2. The markers serve to identify major cell types such as neurons, astrocytes, microglia, oligodendrocytes and endothelial cells and their functional state in the central nervous system (CNS). The kit is optimized for use in FFPE human and mouse tissue sections.
Study neurodegeneration spatial complexity in context
Pathological proteins have emerged as a common mechanism for the progression of various neurodegenerative diseases. Discover the spatial distribution of these key proteins in neural tissues using pre-designed IMC panels for the study of neurodegenerative diseases in FFPE tissue sections.
Target disease-specific markers with ready-to-go panels.
Detect phosphorylated proteins to better understand disease state.
Easily customize panels with your own antibodies or with other IMC panel kits.
PRODUCTS
Get critical insights into common neurodegenerative proteinopathies or mixed pathologies as seen in synucleinopathy and tauopathy neurodegenerative conditions.
Alzheimer's Disease IMC Panel, 3 Antibodies
The Alzheimer’s Disease IMC Panel is a bundle of three verified Maxpar OnDemand antibodies against Tau, phosphorylated Tau (pTau) and amyloid precursor protein (APP).
Parkinson's Disease IMC Panel, 3 Antibodies
The Parkinson’s Disease IMC Panel is a bundle of three verified Maxpar OnDemand antibodies against αSynuclein (αSyn), phosphorylated αSynuclein (p-αSyn) and tyrosine hydroxylase (TH).
Multiple Sclerosis IMC Panel, 3 Antibodies
The Multiple Sclerosis IMC Panel is a bundle of three verified Maxpar OnDemand antibodies against human- and mouse-reactive myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and pan-axonal neurofilament (NF) protein.
Proteinopathies IMC Panel, 5 Antibodies
The Proteinopathies IMC Panel, 5 Antibodies is a bundle of 5 verified Maxpar OnDemand Antibodies against Tau, pTau, αSyn, p-αSyn, and APP. By leveraging these validated antibodies, researchers can visualize cellular landscape of common neurodegenerative proteinopathies such as Alzheimer’s disease, Parkinson’s disease, Parkinson’s disease with dementia, Lewy body dementia, and similar conditions. This panel is optimized for use in FFPE tissue sections. APP, Tau, and αSyn are human and mouse reactive, while p-αSyn and pTau recognize human epitopes [S129] and [S202/T205], respectively, and can be used in mouse models that exogenously express these human proteins.
SynTau Mixed Pathology IMC Panel, 4 Antibodies
The SynTau Mixed Pathology IMC Panel, 4 Antibodies is a bundle of 4 verified Maxpar OnDemand Antibodies designed for unraveling the complexities of mixed pathologies as seen in synucleinopathy and tauopathy neurodegenerative conditions. These antibodies specifically target Tau, pTau, αSyn, and p-αSyn. This panel is optimized for use in FFPE tissue sections and can be used in mouse models that exogenously contain human epitopes for p-αSyn and pTau. Both Tau and αSyn are cross-reactive for human- and mouse-specific targets, while p-αSyn and pTau recognize human epitopes [S129] and [S202/T205], respectively.
Add compatible panels for deeper insights
Capture a more complete view of neurodegeneration by adding compatible products to further characterize immune cell subtypes and tissue structure.
Hover on each panel to view target markers.
Capture a more complete view of neurodegeneration by adding compatible products to further characterize immune cell subtypes and tissue structure.
Click on each panel to view target markers.
See how three different high-parameter 41-marker panels for neurodegenerative disease can be easily assembled, with a particular focus on insights from Alzheimer’s disease tissue.
Webinar: Spatial Dissection Of Tumor Immune Microenvironment
Daniela Quail, PhD
Assistant Professor, Rosalind and Morris Goodman Cancer Institute and Department of Physiology, McGill University
Quail describes the use of Imaging Mass Cytometry to understand immune dynamics in tumors – first in the brain tumor microenvironment to identify new cell populations that might help understand tumor biology and second in non-small-cell lung cancer patients to predict recurrence and survival outcomes.
Posters
Human
Glioblastoma
Human Neurodegenerative Disease
Human Neuro
Oncology
Mouse Neuro
Oncology
Standard BioTools Services Lab
Save 20% off on selected panels with a limited-time promotion until December 31, 2024.
Services Lab
Panel design | Sample prep | Staining | Analysis
Offering flow cytometry and tissue imaging services along with Custom Conjugation Services, the Services Lab provides end-to-end solutions to ensure that you get the most out of your precious samples.
Sample-to-answer custom servicesFor Research Use Only. Not for use in diagnostic procedures. Patent and License Information: www.standardbio.com/legal/notices. Trademarks: www.standardbio.com/legal/trademarks. Any other trademarks are the sole property of their respective owners. ©2024 Standard BioTools Inc. All rights reserved.