Singapore Immunology Network & Standard BioTools High-Dimensional (HiDi) Immune Profiling Research Award 2023
Congratulations to our Research Award winners
Grand Awardee
Institute |
Project Title |
|---|---|
| Lee Kong Chian School of Medicine | Longitudinal cellular and molecular immune features of non-COVID 19 pneumonia in Asian adults |
Our Research Award goes to the institutes below and their projects.
Institute |
Project Title |
|---|---|
| Agency for Science, Technology and Research (A*STAR) | Profiling immune response to PARP inhibitors |
| Chiang Mai University | Immune profiling by mass cytometry to identify immune cell populations that correlate with adult-onset immunodeficiency due to anti-interferon-gamma autoantibodies |
| Flinders University | Characterisation of peripheral blood cell populations from rheumatoid arthritis patients with synovial tissue dominated by lymphoid or myeloid cells |
| National University of Singapore | Evaluation of human lymphoid tissue-derived organoids for recapitulating immunological functions in vivo |
| Singapore Immunology Network | Investigating serotonin receptor 5-HT2A signalling across multiple immune cell lineages as a potential immunotherapy target for liver cancer |
This research award is co-sponsored by Singapore Immunology Network (SIgN) and Standard BioTools™, and six abstracts were selected from numerous applications. The awarded research will be performed using a combination of Standard BioTools Maxpar® Direct™ Immune Profiling Assay™ and Helios™, a CyTOF® mass cytometer, located at SIgN.
The Maxpar Direct Immune Profiling Assay, designed and optimized for deep immuno-monitoring of human peripheral whole blood and PBMC, sets a new standard in immune profiling. The 30 antibodies in the kit are provided in a dry single-tube format that includes Cell-ID™ Intercalator-103Rh for identification of live/dead cells. The assay enables comprehensive identification and characterization of 37 immune cell populations, including all major T cell subsets (CD4+ and CD8+ naive, central memory, effector memory and terminal effector), CD4+ regulatory T cells, mucosal-associated invariant T cells (MAIT)/natural killer T (NKT) cells, B cell subsets (naive and memory, plasmablasts), natural killer (early and late) cells, T helper (Th) cell phenotypic subsets (Th1-like, Th2-like and Th17-like), gamma delta T cells, monocytes (classical, transitional and nonclassical), dendritic cell subsets (plasmacytoid and myeloid), granulocytes, basophils, eosinophils and neutrophils. The assay kit includes all Standard BioTools reagents needed for cell staining, so users need only to add in PBMC, allowing for highly reproducible results.
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