Immuno-Oncology
Explore immune response with spatial biology insights
The tumor microenvironment (TME) represents a complex landscape of cancerous, normal and immune cells within diverse cellular neighborhoods and niches. Understanding the spatial dynamics of cells and tissues and their interplay is crucial for comprehending and treating cancer and requires advanced imaging technologies capable of capturing multiparametric spatial data at high throughput.
Now, researchers can interrogate the TME with the fastest, most comprehensive approach by using new whole slide imaging modes for Imaging Mass Cytometry™ (IMC™), enabling high-multiplex imaging to advance immuno-oncology studies.
Standardized panels to easily interpret tissue heterogeneity
Quickly develop a deep understanding of cancer-related processes in the tumor microenvironment with human- and mouse-specific panels that enable detection of tumor-infiltrating lymphocytes, immune activation and tissue architecture.
New Products
Glioblastoma IMC™ Panel, 5 Antibodies
The Glioblastoma IMC™ Panel, 5 Antibodies provides essential markers for the identification and characterization of glioblastoma cells. This panel includes 4 Maxpar OnDemand Antibodies targeting epidermal growth factor receptor (EGFR), nestin, SOX2, matrix metalloproteinase-9 (MMP9), and 1 Maxpar antibody targeting vimentin. This panel is optimized for use in human FFPE tissue sections, with reported reactivity in mouse.
Human T Cell Exhaustion IMC™ Panel, 5 Antibodies
The Human T Cell Exhaustion IMC™ Panel, 5 Antibodies (201519) provides essential markers for the identification and study of exhausted T cells. This panel includes 5 pathologist-verified antibodies that target CD152/CTLA-4, CD223/LAG-3, CD366/TIM-3, CD134/OX40, and IDO, which enable the assessment of immune dysfunction in chronic infections and cancer and help guide development of effective immunotherapies. The Human T Cell Exhaustion IMC Panel is fully compatible with the Human Immuno-Oncology IMC Panel, 31 Antibodies (201509) and is optimized for use in FFPE human tissue sections using Imaging Mass Cytometry (IMC).
Human Myeloid IMC Panel, 6 Antibodies
The Human Myeloid IMC™ Panel, 6 Antibodies delineates myeloid cell subtypes of immune cell infiltrates in tumors. This panel includes 6 pathologist-verified antibodies that enable phenotyping of monocytes, granulocytes, macrophages, and dendritic cells. This panel is optimized for use in FFPE human tissue sections.
Human Epithelial and Mesenchymal IMC Panel, 4 Antibodies
The Human Epithelial and Mesenchymal IMC™ Panel, 4 Antibodies identifies activation of cellular processes associated with cancer cell signaling and metastasis. This panel includes 5 pathologist-verified antibodies that enable assessment of malignant cell transformation, biomarkers of epithelial to mesenchymal transition, and signaling pathway activation that promotes cancer progression. This panel is optimized for use in FFPE human tissue sections.
Human Tissue Architecture IMC Panel, 4 Antibodies
The Human Tissue Architecture IMC™ Panel, 4 Antibodies identifies the underlying cellular and structural architecture of normal and diseased human tissues. This panel includes 4 pathologist-verified antibodies that enable identification of vasculature, epithelial cells, and components of the extracellular matrix. This panel is optimized for use in FFPE human tissue sections.
Human Lymphoid IMC Panel, 4 Antibodies
The Human Lymphoid IMC™ Panel, 4 Antibodies delineates lymphoid cell subtypes of immune cell infiltrates in tumors. This panel includes 4 pathologist-verified antibodies that enable phenotyping of helper and cytotoxic T cells, memory T cells, B cells, and natural killer cells. This panel is optimized for use in FFPE human tissue sections.
Let us do the work for you.
Did you know Standard BioTools™ has an in-house service lab? Send us your samples and we will send you the data.
New in IMC for immuno-oncology
Reveal Heterogeneity of Tumors With Whole Slide Imaging
This application note highlights the capability of IMC whole slide imaging together with ready-to-go human immuno-oncology IMC panels to provide streamlined and extensive evaluation of the human tumor microenvironment. This fast and comprehensive approach means researchers can quickly capture biological insights across the whole tumor at the single-cell level.
New imaging modes in immuno-oncology applications
View a lookbook showcasing translational and clinical applications of multiplexed tissue analysis of tumor samples.
Co-detection of RNA and protein
Deciphering the spatial arrangement of cell types within the TME could be crucial in empowering the next immuno-oncology breakthroughs. Co-detection of RNA and protein using IMC is a novel approach that enables interrogation of gene expression specific to a cell type of interest and identification of the source of a secreted protein, all in the context of the spatial landscape.
IMC Trending Topics in Immuno-Oncology
This article covers the latest research and past publications using IMC to explore the tumor-immune landscape, biomarker discovery and methods associated with therapeutics development.
Immuno-oncology e-book
In this e-book, two articles selected from the Drug Target Review highlight findings that researchers believe could be used to enhance immunotherapies. This is supplemented with a short Expert View article on using IMC to accelerate success in cancer immunotherapy development.
Jana Fischer, PhD
Co-Founder and CEO, Navignostics
Using spatial biology to navigate treatments for each cancer patient
Hear how the team at Navignostics is translating spatial insights into the clinic by using single-cell spatial data to generate actionable reports on tumor features within 72 hours of sample receipt, revolutionizing treatment decisions for each cancer patient.
Customer Stories
Learn more about how our customers are leveraging Standard BioTools™ technology
Jana Fischer, PhD
Paving a new road for spatial biology in precision medicine
Hartland Jackson, PhD
Entering an era of new biology
Corinne Ramos, PhD, MBA
Advancing drug development with molecular imaging
Yongpan Yan, PhD
An approach that combines molecular biology, immunology and cell biology tools to uniquely
Posters
Poster: Reveal the Heterogeneity of Glioblastoma and Other Tumors Using High-Plex IMC Empowered by Whole Slide Imaging Modes
Poster: Novel Whole Slide Imaging Modes for Imaging Mass Cytometry Reveal Cellular and Structural Composition of Mouse Glioblastoma
Poster: Novel Whole Slide Imaging Modes for Imaging Mass Cytometry Unveil Extensive Cellular Heterogeneity in Human Gliomas
Poster: Next Generation of Spatial Biology: High-Thoroughput Multiplexed Imaging Mass Cytometry With Whole Slide Modes
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