Exposing T cell exhaustion
with a ready-made imaging panel
Exposing T cell exhaustion
with a ready-made imaging panel
Assess immune dysfunction in chronic viral infections and cancer and help guide development of effective immunotherapies with the new Human T Cell Exhaustion IMC™ Panel, 5 Antibodies.
T cell exhaustion is a crucial mechanism that allows tumors to evade the immune system. Identifying exhausted T cells and their spatial proximity to other immune or tumor cells can help predict patient responses to immunotherapy.
Figure shows CD8 T cells in an exhausted state due to co-expression of inhibitory receptors like TIM-3, LAG-3 and PD-1 in human urothelial carcinoma. CD8, CD66b, β-catenin and PD-1 are markers included in the Human Immuno-Oncology IMC Panel, 31 Antibodies.
Capture spatial
biomarkers
Identify exhaustion markers to inform immune dysfunction or stratify patients.
Include
relevant targets
- CD152/CTLA-4
- CD223/LAG-3
- CD336/TIM-3
- CD134/0X40
- IDO
Detect with Imaging Mass Cytometry™ technology
Rapid and detailed assessment of tissue structure and cell features with subcellular resolution
Interpret tissue heterogeneity
Quickly develop a deep understanding of T cell exhaustion within the tumor microenvironment by adding on the Human Immuno-Oncology IMC Panel, 31 Antibodies (PN 201509).
Reagents
View moreHuman T Cell Exhaustion IMC™ Panel, 5 Antibodies
The Human T Cell Exhaustion IMC™ Panel, 5 Antibodies (201519) provides essential markers for the identification and study of exhausted T cells. This panel includes 5 pathologist-verified antibodies that target CD152/CTLA-4, CD223/LAG-3, CD366/TIM-3, CD134/OX40, and IDO, which enable the assessment of immune dysfunction in chronic infections and cancer and help guide development of effective immunotherapies. The Human T Cell Exhaustion IMC Panel is fully compatible with the Human Immuno-Oncology IMC Panel, 31 Antibodies (201509) and is optimized for use in FFPE human tissue sections using Imaging Mass Cytometry (IMC).
Human Myeloid IMC Panel, 6 Antibodies
The Human Myeloid IMC™ Panel, 6 Antibodies delineates myeloid cell subtypes of immune cell infiltrates in tumors. This panel includes 6 pathologist-verified antibodies that enable phenotyping of monocytes, granulocytes, macrophages, and dendritic cells. This panel is optimized for use in FFPE human tissue sections.
Human Epithelial and Mesenchymal IMC Panel, 4 Antibodies
The Human Epithelial and Mesenchymal IMC™ Panel, 4 Antibodies identifies activation of cellular processes associated with cancer cell signaling and metastasis. This panel includes 5 pathologist-verified antibodies that enable assessment of malignant cell transformation, biomarkers of epithelial to mesenchymal transition, and signaling pathway activation that promotes cancer progression. This panel is optimized for use in FFPE human tissue sections.
Human Tissue Architecture IMC Panel, 4 Antibodies
The Human Tissue Architecture IMC™ Panel, 4 Antibodies identifies the underlying cellular and structural architecture of normal and diseased human tissues. This panel includes 4 pathologist-verified antibodies that enable identification of vasculature, epithelial cells, and components of the extracellular matrix. This panel is optimized for use in FFPE human tissue sections.
Human Lymphoid IMC Panel, 4 Antibodies
The Human Lymphoid IMC™ Panel, 4 Antibodies delineates lymphoid cell subtypes of immune cell infiltrates in tumors. This panel includes 4 pathologist-verified antibodies that enable phenotyping of helper and cytotoxic T cells, memory T cells, B cells, and natural killer cells. This panel is optimized for use in FFPE human tissue sections.
Panel design at your fingertips
Build IMC panels directly in your browser. Choose from our large catalog of panels and antibodies without overlap, overcoming the common challenges, complexity and labor involved in panel design.
Resources
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