TEcHNICAL NOTE
Imaging Mass Cytometry (IMC) Technology Uniquely Detects Low-Abundance Biomarkers
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Imaging Mass Cytometry (IMC) Technology Uniquely Detects Low-Abundance Biomarkers
How the high dynamic range of IMC systems reveals variation in protein expression for better assessment of important markers such as PD-1, PD-L1 and CTLA-4
In this technical note, we outline:
- Why the high dynamic range of IMC technology is critical for protein quantification, enabling the assessment of expression level without saturation of signals
- The significance of detecting low-level marker expression, highlighting PD-1, PD-L1 and CTLA-4
- How IMC technology allows for clear analysis of low-abundance markers
- Examples of PD-1, PD-L1 and CTLA-4 marker expression analysis using IMC systems
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