Data in days!
Install, train, run, results.
Can you imagine going from training to results in just a week? The IMSS-CIBIOR (Mexican Institute of Social Security and Eastern Biomedical Research Center) team accomplished this with the help of CyTOF® technology, completing their training on CyTOF XT™, generating data and finishing a poster in days.
Their new work focuses on better understanding the COVID-19 clinical spectrum in Mexico, in an effort to support crucial intervention and prevent the progression to severe disease.
Mexico has one of the highest excess mortality rates due to COVID-19, with pre-existing metabolic conditions posing a challenge in resolving acute infections that largely depend on the prompt response of a functional hematopoietic system. In order to reduce fatality rates around the world, we must attain a comprehensive understanding of the relationship between the development of severe forms of COVID-19 and comorbidities, including obesity, diabetes and chronic kidney disease.
By evaluating the contribution of clinical characteristics and pre-conditions to emergency hematopoiesis and immune response using CyTOF, the team discovered that fatal outcomes were marked by an inflammatory landscape, leading to imbalanced emergency myelopoiesis.
The study investigated cellular and inflammatory parameters in a cohort of 245 COVID-19 patients who were treated and hospitalized but were not in need of invasive mechanical ventilation. Patients who had received SARS-CoV-2 vaccination, or who had previous SARS-CoV-2 infections, were excluded.
Findings showed comorbidities increased the development of an imbalanced myeloid phenotype, leading to middle-aged individuals unable to effectively control disease progression. Chronic comorbidities resulted in a pro-inflammatory microenvironment that triggered severe COVID-19. Identifying pre-existing health conditions along with associated cell populations can help generate predictive signatures to inhibit the disease.
Stay tuned for more exciting work from this group!
Check out their poster, recently presented at the Immuno-Zambia conference.
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