Featured Publications
Combining xenium in situ spatial transcriptomics and imaging mass cytometry on a single tissue section
In this new preprint, researchers at the University of Sydney combined spatial transcriptomics with IMC, revealing differences between RNA and protein expression at the single-cell level during an immune response. The same-slide omics approach offers a more comprehensive view of cellular landscapes and provides a greater depth of functional capabilities and cellular interactions.
Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases
A new study from Columbia University used transcriptomics and IMC to phenotype immune cells in the meninges to reveal novel immune mechanisms in challenging tissues. The publication provides a detailed map of the leptomeningeal part of immune system and is the first time CNS-border T cell behavior has been mapped in detail in the human brain, improving our understanding of neurodegenerative mechanisms, immune surveillance and therapeutic targeting.